A recent scientific study reveals that a morning glass of orange juice is more than just a simple dietary habit. Its impact may extend to thousands of genes within the body, particularly those related to immune system function and cardiovascular health.
The findings suggest that consuming half a liter of natural orange juice daily for two months can trigger previously underestimated biological changes. The study indicates a notable decrease in the activity of several genes associated with physical stress and inflammation, including NAMPT, IL6, IL1B, and NLRP3, among participants who regularly consumed the juice.
Furthermore, the activity of the SGK1 gene, responsible for the kidneys’ role in sodium retention, also decreased. This could contribute to lower blood pressure and support heart health. These findings are consistent with previous research linking daily orange juice consumption to improved blood pressure indicators in adults.
Scientists believe that hesperidin, a natural flavonoid with antioxidant and anti-inflammatory properties, is a key contributor to these benefits. Hesperidin also plays a role in regulating sugar and cholesterol levels.
The data also reveals that the response to orange juice varies among individuals. Overweight individuals showed greater changes in genes related to fat metabolism, while the juice appeared to have a stronger impact on inflammatory markers in individuals with a normal weight.
A review involving 639 participants from 15 studies showed that consistent juice consumption reduces insulin resistance and lowers total cholesterol, both crucial factors in the development of diabetes and heart disease. Analyses further indicate that overweight adults may experience a slight decrease in systolic blood pressure and an increase in good cholesterol (HDL) levels after weeks of juice consumption, benefits that could become significant over the long term.
Emerging studies also point to the juice’s effect on metabolic pathways related to energy, inflammation, and cellular communication, as well as improving gut bacteria composition by increasing bacteria that produce short-chain fatty acids beneficial for health. Despite traditional warnings about the sugars in juices, recent scientific evidence suggests that a moderate glass of natural juice daily can be a beneficial part of the diet, provided it is consumed without additives and in moderation. Researchers maintain that whole fruit remains the best option due to its fiber content.



